Abstract: The formation of ocular neovascular is a complex pathophysiological process, which regulated by varieties factors, vascular endothelial growth factor is considered to be one of the critical factors in the process. The VEGF family members include: VEGFA, VEGFB, VEGFC, VEGFD, VEGFE, VEGFF and Placental growth factor (PIGF). VEGF receptors include VEGFR1, VEGFR2, VEGFR3 Each receptor can be activated by the same or diffident VEGF for various physiological functions. Research on VEGFA and its receptor is the most, which has different sites and modes to angiogenesis, lead to produce a variety of drugs and clinical medicine and treatment programs for ocular neovascular diseases has been changed largely. With the indepth study of the VEGF family and its receptors, researchers gradually find the other members of the VEGF family like VEGFB, which has different target and mechanism with VEGFA. This review summarizes the research of VEGF family and its receptor include mechanism, function and different type of antiVEGF treatment, clinical applications and research progress.  (Int Rev Ophthalmol, 2014, 38: 123-128)